⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909288 | 1.00 | — | — | |
| SCHEMBL869800 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL27871150 | 0.98 | KDM4E (0.42) | — | |
| Piperazine SCHEMBL28120340 | 0.98 | KDM4E (0.42) | — | |
| Hydrochloric Acid SCHEMBL27837986 | 0.98 | KDM4E (0.42) | — | |
| Acetic Acid SCHEMBL28060482 | 0.92 | KDM4E (0.38) | — | |
| SCHEMBL31714117 | 0.90 | KDM4E (0.46) | — | |
| SCHEMBL31714197 | 0.90 | KDM4E (0.46) | — | |
| SCHEMBL28095750 | 0.88 | KDM4E (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL28194920 | 0.87 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 605 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368625-A1 | PIPERAZINES | Grünenthal GmbH (DE) | 2025-12-04 | — | — | US | claimed |
| EP-4518853-A1 | OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2025-03-12 | — | — | EP | claimed |
| WO-2023215205-A1 | OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2023-11-09 | — | — | WO | claimed |
| US-20230175026-A1 | Process for the Preparation of a Chiral Piperazine-2-carboxylic Acid | HOFFMANN-LA ROCHE INC. (US) | 2023-06-08 | — | — | US | claimed |
| EP-4143173-A1 | PROCESS FOR THE PREPARATION OF A CHIRAL PIPERAZINE-2-CARBOXYLIC ACID | F. Hoffmann-La Roche AG (CH) | 2023-03-08 | — | — | EP | claimed |
| CN-115461333-A | Process for the preparation of chiral piperazine-2-carboxylic acid | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | claimed |
| CN-110157251-B | Curing agent composition and coating composition comprising same | ＫＣＣ公司 | 2022-04-01 | — | — | CN | claimed |
| WO-2021219523-A1 | PROCESS FOR THE PREPARATION OF A CHIRAL PIPERAZINE-2-CARBOXYLIC ACID | F. HOFFMANN-LA ROCHE AG (CH) | 2021-11-04 | — | — | WO | claimed |
| CN-108160336-B | Tellurium-bismuth ore flotation inhibitor and preparation method and application thereof | 中国地质科学院矿产综合利用研究所 | 2020-11-03 | — | — | CN | claimed |
| CN-108970425-B | Polymer membrane for high-salinity wastewater treatment and preparation method thereof | 张春云 | 2020-09-01 | — | — | CN | claimed |
| EP-1554278-B1 | XANTHINE DERIVATIVES, PRODUCTION THEREOF AND USE THEREOF AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-04-12 | — | — | EP | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |
| US-20040166125-A1 | Xanthine derivatives, their preparation and their use in pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-08-26 | — | — | US | claimed |
| CN-1310629-A | Combined administration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions | WARNER LAMBERT CO (US) | 2001-08-29 | — | — | CN | claimed |
| EP-0756593-B1 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 2000-09-20 | — | — | EP | claimed |
| US-5856485-A | RESOLUTION OF AN ENANTIOMORPH MIXTURE | LONZA AG (CH) | 1999-01-05 | — | — | US | claimed |
| WO-1997044328-A1 | 1-(ALKANOYL HALIDE)-2-CARBOXAMIDO-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1997-11-27 | — | — | WO | claimed |
| EP-0799211-A1 | 2-CARBAMOYL-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019460-A1 | 2-CARBAMOYL-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-27 | — | — | WO | claimed |