Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367276 | 0.89 | ESR1 (0.52) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL2221902 | 0.86 | ESR1 (0.55) | ESR1ESR2HDAC6PKMABHD6 | |
| Hydrochloric Acid SCHEMBL1792810 | 0.84 | ESR1 (0.53) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL1364723 | 0.83 | ESR1 (0.52) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL3284914 | 0.82 | ESR1 (0.51) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL1789769 | 0.81 | ESR1 (0.50) | ESR1ESR2HDAC6PKMMEN1 | |
| SCHEMBL2585109 | 0.81 | ESR1 (0.62) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL1366408 | 0.81 | ESR1 (0.52) | ESR1ESR2HDAC6PKMHDAC8 | |
| SCHEMBL2364766 | 0.80 | ESR2 (0.52) | ESR1ESR2HDAC6PKMABHD6 | |
| SCHEMBL8373032 | 0.79 | ESR1 (0.61) | ESR1ESR2HDAC6PKMABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007149728-A2 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON RESEARCH, LTD. (US) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007149728-A2 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON RESEARCH, LTD. (US) | 2007-12-27 | — | — | WO | disclosed |
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON MANUFACTURING LTD. (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | ALCON MANUFACTURING LTD. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293475-A1 | ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA | HTR2B, HTR2A, HTR3B | ESR1 3694/4885ESR2 667/4885HDAC6 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.