Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922944 | 0.91 | NISCH (0.51) | NISCHGAADYRK1ACLK4MAOB | |
| SCHEMBL31309661 | 0.80 | CHRNB4 (0.57) | NISCHMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5203405 | 0.77 | PDE4B (0.63) | MAOBMAPTALDH1A1KDM4E | |
| SCHEMBL2806024 | 0.76 | CHRNB4 (0.57) | NISCHGAADYRK1ACLK4MAOB | |
| SCHEMBL5309374 | 0.75 | PDE3B (0.63) | GAAMAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3072114 | 0.71 | PDE4B (0.52) | MAOB | |
| SCHEMBL3054495 | 0.71 | PDE4B (0.52) | SMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6773687 | 0.70 | NISCH (0.46) | NISCHGAACLK4MAOBMAPT | |
| SCHEMBL196765 | 0.70 | CYP3A4 (0.73) | NISCHGAADYRK1ACLK4MAOB | |
| SCHEMBL29489425 | 0.70 | CYP3A4 (0.73) | NISCHGAADYRK1ACLK4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |