Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 9/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | RHOC | P08134 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600617 | 0.99 | HMGCR (1.00) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL4730997 | 0.99 | HMGCR (1.00) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL6362203 | 0.96 | HMGCR (1.00) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL5996701 | 0.96 | HMGCR (0.93) | HMGCR | |
| SCHEMBL5224248 | 0.93 | HMGCR (0.88) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL5223752 | 0.93 | HMGCR (0.88) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL5991667 | 0.93 | HMGCR (0.87) | HMGCR | |
| SCHEMBL6418791 | 0.93 | HMGCR (0.87) | HMGCR | |
| SCHEMBL5329253 | 0.93 | HMGCR (0.87) | HMGCR | |
| SCHEMBL5994456 | 0.91 | HMGCR (0.85) | HMGCRNR1I2ABCB11RHOCCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007119473-A | CRYSTALLINE FORM OF (3R,5R)-7-[4-BENZYLCARBAMOYL-2-(4-FLUOROPHENYL)-5-ISOPROPYL-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID SODIUM SALT | PFIZER PROD INC | 2007-05-17 | — | — | JP | disclosed |
| JP-2007119473-A | CRYSTALLINE FORM OF (3R,5R)-7-[4-BENZYLCARBAMOYL-2-(4-FLUOROPHENYL)-5-ISOPROPYL-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID SODIUM SALT | PFIZER PROD INC | 2007-05-17 | — | — | JP | disclosed |