Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 4/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407922 | 0.82 | NR1H2 (0.52) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407435 | 0.82 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407329 | 0.80 | NR1H2 (0.46) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407772 | 0.80 | NR1H2 (0.46) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407372 | 0.80 | NR1H2 (0.50) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1415167 | 0.79 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407083 | 0.79 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407813 | 0.79 | KDM4E (0.44) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407439 | 0.79 | NR1H2 (0.51) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407392 | 0.79 | NR1H2 (0.47) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | claimed |