Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 8/20 | 0.64 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.54 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953561 | 1.00 | GBA1 (0.64) | GBA1FUCA1PYGLESR1ESR2 | |
| Bromide SCHEMBL4532368 | 0.99 | GBA1 (0.63) | GBA1FUCA1PYGLESR1ESR2 | |
| Bromide SCHEMBL1943491 | 0.99 | GBA1 (0.63) | GBA1FUCA1PYGLESR1ESR2 | |
| Bromide SCHEMBL2683848 | 0.99 | GBA1 (0.63) | GBA1FUCA1PYGLESR1ESR2 | |
| SCHEMBL7447584 | 0.89 | FUCA1 (0.63) | GBA1FUCA1ESR1ESR2GRIN2B | |
| SCHEMBL6042485 | 0.89 | FUCA1 (0.63) | GBA1FUCA1ESR1ESR2GRIN2B | |
| SCHEMBL6042482 | 0.89 | FUCA1 (0.63) | GBA1FUCA1ESR1ESR2GRIN2B | |
| SCHEMBL6042917 | 0.88 | GBA1 (0.63) | GBA1FUCA1PYGLRORC | |
| SCHEMBL6043347 | 0.86 | GBA1 (0.60) | GBA1FUCA1PYGLGRIN2BRORC | |
| SCHEMBL500739 | 0.81 | GBA1 (0.82) | GBA1FUCA1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863763-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103275-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |