SCHEMBL533073

SCHEMBL533073

CC(=O)OC(C)(C)Nc1cccc(C(Cc2ccc(-n3cccn3)cc2)NS(=O)(=O)c2cccnc2)n1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER2 P43116 5/20 0.46
PTGER4 P35408 1/20 0.45
NAMPT P43490 7/20 0.38
TP53 P04637 1/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 1/20 0.35
PKM P14618 1/20 0.35
KMT2A Q03164 1/20 0.35
GCGR P47871 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30063042 1.00 PTGER2 (0.46) PTGER2PTGER4NAMPTTP53MAPT
SCHEMBL15412005 0.89 PTGER2 (0.47) PTGER2PTGER4NAMPTTP53MAPT
SCHEMBL533447 0.87 PTGER2 (0.48) PTGER2PTGER4NAMPTTP53MAPT
Hydrochloric Acid SCHEMBL533633 0.84 PTGER2 (0.64) PTGER2PTGER4
SCHEMBL533246 0.84 PTGER2 (0.64) PTGER2PTGER4
SCHEMBL29391537 0.84 PTGER2 (0.67) PTGER2PTGER4NAMPT
SCHEMBL20262519 0.84 PTGER2 (0.67) PTGER2PTGER4NAMPT
SCHEMBL11026034 0.83 PTGER2 (0.49) PTGER2PTGER4NAMPTTP53MAPT
SCHEMBL533546 0.83 PTGER2 (0.47) PTGER2PTGER4NAMPTTP53MAPT
SCHEMBL18204450 0.83 PTGER2 (0.46) PTGER2PTGER4NAMPTTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120190852-A1 MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA UBE INDUSTRIES, LTD. (JP) 2012-07-26 US claimed
EP-2415763-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA Ube Industries, Ltd. (JP) 2012-02-08 EP claimed
US-20230372316-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION SANTEN PHARMACEUTICAL CO., LTD. (JP) 2023-11-23 US disclosed
EP-3888654-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL CONTAINING PHARMACEUTICAL COMPOSITION Santen Pharmaceutical Co., Ltd. (JP) 2021-10-06 EP disclosed
US-20200113880-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION SANTEN PHARMACEUTICAL CO., LTD. (JP) 2020-04-16 US disclosed
EP-3093021-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION Santen Pharmaceutical Co., Ltd (JP) 2016-11-16 EP disclosed
US-20160317512-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION SANTEN PHARMACEUTICAL CO., LTD. (JP) 2016-11-03 US disclosed
CN-105828817-A Pharmaceutical composition containing pyridylaminoacetic acid compound and polyoxyethylated castor oil 参天制药株式会社 2016-08-03 CN disclosed
WO-2015105134-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION 参天製薬株式会社 2015-07-16 WO disclosed
US-20120190852-A1 MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA UBE INDUSTRIES, LTD. (JP) 2012-07-26 US disclosed
EP-2415763-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA Ube Industries, Ltd. (JP) 2012-02-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160317512-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION PAOX, CYP4A11, PAH PTGER2 296/4885PTGER4 237/4885NAMPT 2398/4885
US-20230372316-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION PAOX, CYP4A11, PAH PTGER2 296/4885PTGER4 237/4885NAMPT 2398/4885
US-20200113880-A1 PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING PHARMACEUTICAL COMPOSITION PAOX, CYP4A11, PAH PTGER2 296/4885PTGER4 237/4885NAMPT 2398/4885
US-20120190852-A1 MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA F12, C1S, AKR1C3 PTGER2 24/4885PTGER4 133/4885NAMPT 3499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.