Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | FES | P07332 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.39 |
| ▸ | FER | P16591 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | FRK | P42685 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247887 | 0.84 | DYRK1A (0.40) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL2890696 | 0.81 | BRAF (0.43) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL859210 | 0.80 | PRKD3 (0.49) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL3505473 | 0.80 | BRAF (0.52) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL3505142 | 0.80 | BRAF (0.39) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL2043650 | 0.79 | BRAF (0.37) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL2890699 | 0.76 | BRAF (0.39) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL3715063 | 0.75 | AURKA (0.39) | BRAFDYRK1APLK4AURKAROCK2 | |
| SCHEMBL856994 | 0.74 | BRAF (0.48) | BRAFPLK4AURKAFESFGFR1 | |
| SCHEMBL415757 | 0.74 | BRAF (0.40) | BRAFDYRK1APLK4AURKAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |