Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036162 | 0.84 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1034081 | 0.79 | SLC6A4 (0.76) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1036328 | 0.78 | SLC6A4 (0.74) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1034709 | 0.78 | SLC6A4 (0.59) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1033900 | 0.76 | SLC6A4 (0.75) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1036198 | 0.74 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1035749 | 0.71 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL1034175 | 0.70 | SLC6A4 (0.83) | SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL12956309 | 0.70 | SLC6A4 (0.75) | SLC6A4HRH3 | |
| SCHEMBL1037252 | 0.70 | SLC6A4 (0.76) | SLC6A4HRH3SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831173-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066197-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-06-22 | — | — | WO | claimed |