Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102760 | 0.78 | GRM5 (0.44) | GRM5KCNH2 | |
| SCHEMBL101285 | 0.77 | GRM5 (0.46) | GRM5KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL102652 | 0.77 | GRM5 (0.38) | GRM5KCNH2NPC1HCRTR1RAB9A | |
| SCHEMBL104787 | 0.74 | GRM5 (0.44) | GRM5KCNH2NPC1HCRTR1RAB9A | |
| SCHEMBL103114 | 0.74 | GRM5 (0.46) | GRM5KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL4203163 | 0.70 | GRM5 (0.47) | GRM5KCNH2 | |
| SCHEMBL102453 | 0.70 | GRM5 (0.47) | GRM5HCRTR1FGFR1FGFR2FGFR4 | |
| SCHEMBL103825 | 0.69 | GRM5 (0.44) | GRM5KCNH2 | |
| SCHEMBL102822 | 0.69 | GRM5 (0.43) | GRM5KCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL398327 | 0.69 | EPHB4 (0.43) | GRM5KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | claimed |