Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | FLT3 | P36888 | 10/20 | 0.52 |
| ▸ | KIT | P10721 | 7/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332717 | 0.89 | KDR (0.51) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL1383488 | 0.88 | KDR (0.58) | KDRFLT3KITIKBKEMAPT | |
| SCHEMBL423203 | 0.82 | KDR (0.70) | KDRFLT3KITIKBKEPDGFRB | |
| SCHEMBL1378823 | 0.79 | KDR (0.56) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL4739851 | 0.78 | KDR (0.58) | KDRFLT3KITIKBKEALDH1A1 | |
| SCHEMBL4735824 | 0.78 | KDR (0.72) | KDRFLT3KITIKBKEPDGFRB | |
| SCHEMBL4736503 | 0.77 | IKBKE (0.65) | KDRFLT3KITIKBKEKMT2A | |
| SCHEMBL1379304 | 0.74 | FLT3 (0.62) | KDRFLT3KITIKBKEPDGFRB | |
| SCHEMBL422289 | 0.73 | KDR (0.65) | KDRFLT3KITIKBKEPDGFRB | |
| SCHEMBL420485 | 0.72 | KDR (0.81) | KDRFLT3KITMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |