Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15832409 | 0.85 | MAPT (0.47) | MAPTPOLBSLC34A1NR3C2PTGS2 | |
| SCHEMBL16804455 | 0.83 | MAPT (0.63) | MAPTPOLBPTGS2CA1CA2 | |
| SCHEMBL16210657 | 0.83 | POLB (0.59) | MAPTPOLBPTGS2CA1CA2 | |
| SCHEMBL17112717 | 0.80 | NPC1 (0.50) | MAPTPOLBNR3C2PTGS2CA1 | |
| SCHEMBL27759445 | 0.79 | CA1 (0.67) | NR3C2PTGS2CA1CA2CA9 | |
| SCHEMBL12462094 | 0.79 | NR3C2 (0.59) | NR3C2PTGS2CA1CA2CA9 | |
| SCHEMBL1740586 | 0.78 | POLB (0.57) | MAPTPOLBSIGMAR1 | |
| SCHEMBL4515430 | 0.77 | MAPT (0.60) | MAPTPOLBSLC34A1MAPK1HTT | |
| SCHEMBL1739906 | 0.76 | POLB (0.56) | MAPTPOLBPTGS2CA1CA2 | |
| SCHEMBL27637349 | 0.74 | NR3C2 (0.52) | NR3C2PTGS2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007079086-A1 | PYRAZOLOALKYL SUBSTITUTED IMIDAZO RING COMPOUNDS AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-12 | — | — | WO | disclosed |