Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049939 | 0.97 | ADORA1 (0.36) | MAPK1ADORA1CYP2C9MAPTALDH1A1 | |
| SCHEMBL4057141 | 0.88 | PDE4B (0.41) | MAPK1MAPTALDH1A1HTTPDE4B | |
| SCHEMBL4370564 | 0.87 | ADORA1 (0.36) | ADORA1CYP2C9MAPTALDH1A1HTT | |
| SCHEMBL4057540 | 0.85 | ADORA1 (0.45) | MAPK1ADORA1MAPTALDH1A1HTT | |
| SCHEMBL4051710 | 0.85 | ADORA1 (0.35) | MAPK1ADORA1MAPTALDH1A1HTT | |
| SCHEMBL4059427 | 0.85 | ADORA1 (0.41) | MAPK1ADORA1MAPTALDH1A1HTT | |
| SCHEMBL4050545 | 0.84 | ADORA1 (0.38) | ADORA1CYP2C9MAPTALDH1A1HTT | |
| SCHEMBL4053146 | 0.84 | ADORA1 (0.43) | ADORA1MAPTALDH1A1HTTPDE4B | |
| SCHEMBL4052382 | 0.83 | ADORA1 (0.40) | ADORA1MAPTALDH1A1HTTPDE4B | |
| SCHEMBL4051430 | 0.82 | MAPK1 (0.36) | MAPK1ADORA1CYP2C9MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | claimed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |