SCHEMBL5338150

SCHEMBL5338150

CC(C)(C)OC(=O)N1CCN(c2ccccc2N(CC2CCC2)S(C)(=O)=O)CC1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MC4R P32245 18/20 0.65
LIMK2 P53671 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5338194 0.97 MC4R (0.64) MC4R
SCHEMBL5332549 0.96 MC4R (0.70) MC4RLIMK2
SCHEMBL5335663 0.85 MC4R (0.55) MC4R
SCHEMBL5346578 0.82 MC4R (0.57) MC4R
SCHEMBL4529470 0.82 MC4R (0.57) MC4R
SCHEMBL14355847 0.82 MC4R (0.52) MC4R
SCHEMBL5337267 0.82 MC4R (0.52) MC4R
SCHEMBL4697699 0.81 MC4R (0.55) MC4RLIMK2
SCHEMBL5338171 0.81 MC4R (0.53) MC4R
SCHEMBL5331626 0.81 MC4R (0.55) MC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291619-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2007-11-06 US disclosed
US-7291619-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2007-11-06 US disclosed
EP-1368340-B1 PIPERAZINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS LILLY CO ELI (US) 2005-08-10 EP disclosed
US-20040092507-A1 Melanocortin receptor agonists ELI LILLY AND COMPANY 2004-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092507-A1 Melanocortin receptor agonists MC1R, MC4R, MC5R MC4R 2/4885LIMK2 4439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.