Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 10/20 | 0.77 |
| ▸ | KDR | P35968 | 9/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.68 |
| ▸ | AURKA | O14965 | 10/20 | 0.68 |
| ▸ | TPX2 | Q9ULW0 | 7/20 | 0.68 |
| ▸ | LCK | P06239 | 4/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266652 | 0.89 | TEK (0.89) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264337 | 0.89 | KDR (0.77) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264069 | 0.88 | AURKB (0.64) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1265282 | 0.88 | TEK (0.81) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264040 | 0.87 | TEK (1.00) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL2298875 | 0.87 | KDR (1.00) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264572 | 0.87 | TEK (0.79) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1265717 | 0.87 | TEK (0.81) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264779 | 0.87 | TEK (0.81) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264369 | 0.86 | TEK (0.80) | TEKKDRAURKBAURKATPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |