Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446503 | 0.83 | POLB (0.49) | MAPTPOLBRXFP1MEN1KMT2A | |
| SCHEMBL447629 | 0.82 | MEN1 (0.41) | MAPTPOLBRXFP1ACKR3MEN1 | |
| SCHEMBL6222577 | 0.82 | MEN1 (0.41) | MAPTPOLBRXFP1ACKR3MEN1 | |
| SCHEMBL7119747 | 0.80 | POLB (0.47) | MAPTPOLBRXFP1KDRBRAF | |
| SCHEMBL447394 | 0.78 | RXFP1 (0.44) | MAPTPOLBRXFP1MEN1KMT2A | |
| SCHEMBL445150 | 0.76 | RXFP1 (0.52) | MAPTPOLBRXFP1ACKR3KDR | |
| SCHEMBL6288233 | 0.74 | POLB (0.51) | MAPTPOLBRXFP1KDRBRAF | |
| SCHEMBL444971 | 0.74 | POLB (0.51) | MAPTPOLBRXFP1KDRBRAF | |
| SCHEMBL447926 | 0.74 | POLB (0.50) | MAPTPOLBRXFP1MEN1KMT2A | |
| SCHEMBL27613753 | 0.74 | KDR (0.39) | MAPTPOLBRXFP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773817-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012374-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-02-02 | — | — | WO | disclosed |