Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 6/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674617 | 0.91 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3680525 | 0.84 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL3679762 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL3679312 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3679079 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3675799 | 0.82 | PDE4D (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3673955 | 0.80 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL3676982 | 0.80 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL3671444 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DSSTR5 | |
| SCHEMBL4871798 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869054-A2 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | Ranbaxy Laboratories Limited (IN) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006085212-A2 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | RANBAXY LABORATORIES LIMITED (IN) | 2006-08-17 | — | — | WO | disclosed |