Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346692 | 0.86 | CDK5 (0.45) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5346073 | 0.85 | CDK5 (0.54) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5341539 | 0.85 | CDK5 (0.50) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5343883 | 0.85 | CDK5 (0.56) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5342625 | 0.84 | CDK5 (0.53) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL14558866 | 0.84 | CDK5 (0.53) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5342684 | 0.84 | CDK5 (0.62) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5352258 | 0.84 | CDK5 (0.53) | CDK5CDK5R1DYRK1AGRM4CCNA2 | |
| SCHEMBL5348280 | 0.84 | CDK5 (0.53) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5348448 | 0.84 | CDK5 (0.59) | CDK5CDK5R1DYRK1ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | claimed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |