Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378900 | 0.93 | KDR (0.47) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL378585 | 0.93 | KDR (0.56) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL3083938 | 0.91 | KDR (0.56) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL3096969 | 0.88 | KDR (0.59) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL378412 | 0.87 | KDR (0.44) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL378723 | 0.87 | EGFR (0.41) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL3093307 | 0.86 | KDR (0.59) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL3079700 | 0.86 | KDR (0.57) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL4850300 | 0.85 | KDR (0.52) | KDREGFRFGFR1ABL1RET | |
| SCHEMBL7830884 | 0.84 | KDR (0.47) | KDREGFRFGFR1ABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784183-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | Pfizer Products Incorporated (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006026034-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2006-03-09 | — | — | WO | claimed |