Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 7/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347596 | 0.95 | HRH2 (0.41) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5345751 | 0.83 | HRH2 (0.47) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5345679 | 0.80 | HRH2 (0.69) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5348368 | 0.80 | HRH2 (0.65) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5348252 | 0.78 | HRH2 (0.49) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5345520 | 0.78 | HRH2 (0.65) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5346738 | 0.78 | HRH2 (0.65) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL5344785 | 0.76 | HRH2 (0.69) | HTR6DRD2HRH2HTR2AHTR2C | |
| SCHEMBL4055511 | 0.72 | HRH2 (0.53) | HTR6HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4701463 | 0.72 | SLC6A2 (0.53) | HTR6HTR2CHTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |