Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.48 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.48 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.48 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351482 | 0.93 | NPC1 (0.60) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4633366 | 0.89 | NPC1 (0.67) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4828232 | 0.87 | NPC1 (0.67) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4632753 | 0.85 | NPC1 (0.62) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4632702 | 0.85 | NPC1 (0.65) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4828131 | 0.83 | HTT (0.64) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4832178 | 0.83 | NPC1 (0.62) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4833960 | 0.83 | NPC1 (0.62) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL4632730 | 0.83 | NPC1 (0.62) | NPC1MAPTGUSBHTTKDM4E | |
| SCHEMBL5348906 | 0.83 | NPC1 (0.65) | NPC1MAPTGUSBHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265122-B2 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2007-09-04 | — | — | US | disclosed |