Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391136 | 0.87 | NPC1 (0.50) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL391137 | 0.87 | NPC1 (0.50) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL391138 | 0.87 | NPC1 (0.50) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL393071 | 0.86 | NPC1 (0.49) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL393072 | 0.86 | NPC1 (0.49) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL393070 | 0.86 | NPC1 (0.49) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL1173868 | 0.84 | NPC1 (0.54) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL51234 | 0.83 | NPC1 (0.53) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL8877622 | 0.77 | APP (0.54) | NPC1ASH1LKIF11PARP1GPR84 | |
| SCHEMBL5447383 | 0.76 | NPC1 (0.48) | NPC1ASH1LKIF11PARP1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092000-A1 | INHIBITORS OF HCV REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |