Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352132 | 1.00 | USP30 (0.55) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5352138 | 1.00 | USP30 (0.55) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5353583 | 0.94 | MKNK1 (0.55) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5354171 | 0.94 | MKNK1 (0.55) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5353588 | 0.94 | MKNK1 (0.55) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5367612 | 0.87 | MKNK1 (0.57) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL14408016 | 0.83 | CNR2 (0.63) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5354063 | 0.81 | MKNK1 (0.64) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL5359220 | 0.80 | MKNK1 (0.57) | USP30MKNK1UCHL1KDRCNR2 | |
| SCHEMBL14408019 | 0.79 | CNR2 (0.66) | USP30MKNK1UCHL1KDRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265134-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |