SCHEMBL5358129

SCHEMBL5358129

COc1cc(F)c(Bc2c(F)cc(OC)cc2F)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.48
ALDH1A1 P00352 2/20 0.48
CYP1A1 P04798 5/20 0.40
CYP1B1 Q16678 5/20 0.40
CYP1A2 P05177 3/20 0.40
NQO2 P16083 1/20 0.36
CYP3A4 P08684 3/20 0.36
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA12 O43570 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
CPS1 P31327 1/20 0.34
CYP2E1 P05181 2/20 0.33
CYP2C8 P10632 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2A6 P11509 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP4B1 P13584 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6063724 0.93 TAAR1 (0.44) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6062229 0.89 TAAR1 (0.41) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6063358 0.88 TAAR1 (0.40) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6062206 0.86 TAAR1 (0.39) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL5355149 0.86 TAAR1 (0.39) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6062677 0.84 TAAR1 (0.38) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL5346533 0.84 TAAR1 (0.38) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6062209 0.84 TAAR1 (0.38) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL5353065 0.84 TAAR1 (0.38) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2
SCHEMBL6062720 0.84 TAAR1 (0.38) TAAR1ALDH1A1CYP1A1CYP1B1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7217676-B2 Hydrophobization and silica for supported catalyst EXXON MOBIL CHEMICAL PATENTS INC. (US) 2007-05-15 US disclosed
US-20060264320-A1 Hydrophobization and silica for supported catalyst RODRIGUEZ GEORGE 2006-11-23 US disclosed
EP-1704171-A2 HYDROPHOBIZATION AND SILICA FOR SUPPORTED CATALYST ExxonMobil Chemical Patents Inc. (US) 2006-09-27 EP disclosed
WO-2005075526-A2 HYDROPHOBIZATION AND SILICA FOR SUPPORTED CATALYST EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-08-18 WO disclosed
US-20050159299-A1 Hydrophobization and silica for supported catalyst EXXONMOBIL CHEMICAL PATENTS INC. 2005-07-21 US disclosed