Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.38 |
| ▸ | CDK9 | P50750 | 10/20 | 0.38 |
| ▸ | BTK | Q06187 | 6/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001595 | 0.97 | CCNT1 (0.38) | CCNT1CDK9BTKPRKD1 | |
| SCHEMBL5004683 | 0.91 | CCNT1 (0.48) | SYKCCNT1CDK9 | |
| SCHEMBL13994144 | 0.91 | CCNT1 (0.48) | CCNT1CDK9BTK | |
| SCHEMBL5010180 | 0.90 | RIPK2 (0.45) | — | |
| SCHEMBL5010242 | 0.90 | CCNT1 (0.38) | SYKCCNT1CDK9BTK | |
| SCHEMBL13994165 | 0.89 | CCNT1 (0.41) | CCNT1CDK9BTK | |
| SCHEMBL5008417 | 0.89 | KCNH2 (0.42) | SYKCCNT1CDK9BTK | |
| SCHEMBL5004735 | 0.88 | CCNT1 (0.40) | CCNT1CDK9BTK | |
| SCHEMBL13994111 | 0.88 | CCNT1 (0.41) | CCNT1CDK9PRKD1 | |
| SCHEMBL13994106 | 0.88 | CCNT1 (0.43) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797054-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017443-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |