Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.71 |
| ▸ | TLK2 | Q86UE8 | 7/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 4/20 | 0.61 |
| ▸ | FLT3 | P36888 | 3/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728024 | 0.83 | TLK2 (1.00) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL5728025 | 0.83 | TLK2 (1.00) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL5369374 | 0.80 | TLK2 (0.71) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL19692 | 0.79 | PDPK1 (1.00) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL19691 | 0.79 | PDPK1 (1.00) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL8530176 | 0.78 | KDM4E (0.52) | PDPK1TLK2PDGFRBRETFLT3 | |
| SCHEMBL8584423 | 0.77 | NTRK1 (0.63) | PDPK1TLK2PDGFRBKDRPDGFRA | |
| SCHEMBL8584419 | 0.77 | NTRK1 (0.63) | PDPK1TLK2PDGFRBKDRPDGFRA | |
| SCHEMBL20763 | 0.77 | TLK2 (0.70) | PDPK1TLK2PDGFRBKDRFLT1 | |
| SCHEMBL5361502 | 0.77 | PDPK1 (0.64) | PDPK1TLK2PDGFRBKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | PDPK1 31/4885TLK2 48/4885PDGFRB 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.