Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.63 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.63 |
| ▸ | LTK | P29376 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.63 |
| ▸ | CDK7 | P50613 | 2/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.63 |
| ▸ | MST1R | Q04912 | 2/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.63 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.63 |
| ▸ | CDK8 | P49336 | 1/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132142 | 0.86 | NTRK1 (0.58) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL7780481 | 0.82 | NTRK1 (0.83) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5361625 | 0.81 | MDM2 (0.53) | NTRK1NTRK3NTRK2RETSYK | |
| SCHEMBL5357671 | 0.81 | LRRK2 (0.51) | NTRK1NTRK3NTRK2RETSYK | |
| SCHEMBL14448937 | 0.78 | NTRK1 (1.00) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5472269 | 0.78 | NTRK1 (1.00) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5373328 | 0.78 | LRRK2 (0.52) | NTRK1RETCSNK1A1CYP1A2CYP2C19 | |
| SCHEMBL5201532 | 0.78 | NTRK1 (1.00) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5203073 | 0.77 | NTRK1 (0.75) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5201825 | 0.77 | NTRK1 (0.75) | NTRK1NTRK3NTRK2PRKD3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | NTRK1 223/4885NTRK3 358/4885NTRK2 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.