Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.76 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | MEN1 | O00255 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | HPGD | P15428 | 5/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.76 |
| ▸ | RECQL | P46063 | 5/20 | 0.76 |
| ▸ | BLM | P54132 | 5/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 4/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362194 | 1.00 | EGFR (0.76) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5362185 | 1.00 | EGFR (0.76) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1934512 | 0.94 | MAPT (0.75) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29378814 | 0.87 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL645291 | 0.87 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL645290 | 0.87 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10118843 | 0.84 | EGFR (0.82) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29376415 | 0.83 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2533402 | 0.83 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6055311 | 0.83 | EGFR (1.00) | EGFRMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217737-B2 | Method and compositions for inhibiting cell proliferative disorders | YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2007-05-15 | — | — | US | disclosed |
| US-20040242684-A1 | Method and compositions for inhibiting cell proliferative disorders | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM | 2004-12-02 | — | — | US | disclosed |
| US-6596878-B2 | Protein kinase inhibitor compositio; used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR. | YISSUM RESEARCH & DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY (IL) | 2003-07-22 | — | — | US | disclosed |
| US-20020068687-A1 | Methods and compositions for inhibiting cell proliferative disorders | CHEN HUI (US) | 2002-06-06 | — | — | US | disclosed |
| US-5789427-A | ANTITUMOR, ANTICANCER AGENTS | SUGEN, INC. (US) | 1998-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242684-A1 | Method and compositions for inhibiting cell proliferative disorders | ERBB2, EGFR, MKI67 | EGFR 2/4885MAPT 2232/4885MEN1 2723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.