Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GRN | P28799 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.35 |
| ▸ | ATP4B | P51164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924173 | 0.80 | GRN (0.49) | TSHRGRNSORT1ALDH1A1L3MBTL1 | |
| SCHEMBL5464352 | 0.79 | TSHR (0.40) | TSHRPTGER1CYP1A2ALDH1A1HTR2A | |
| SCHEMBL5363238 | 0.76 | SMN1; SMN2 (0.49) | TSHRPTGER1CYP1A2ALDH1A1MAPT | |
| SCHEMBL25183328 | 0.73 | POLB (0.35) | MAPTPOLB | |
| SCHEMBL251373 | 0.72 | PTGER1 (0.71) | PTGER1CYP1A2 | |
| SCHEMBL10080823 | 0.71 | HTR2C (0.71) | TSHRGRNSORT1ALDH1A1HTR2A | |
| SCHEMBL5359814 | 0.70 | HDAC1 (0.43) | TSHRPTGER1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3086653 | 0.69 | HTR2C (0.50) | HTR2AHTR2CSLC6A4L3MBTL1SMN1; SMN2 | |
| SCHEMBL16804455 | 0.68 | MAPT (0.63) | CYP1A2ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL12102938 | 0.68 | POLB (0.42) | ALDH1A1MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |