Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.45 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136788 | 0.84 | PDGFRB (0.58) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5392303 | 0.84 | PDGFRB (0.74) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5369688 | 0.81 | KDR (0.51) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL19255670 | 0.77 | PDGFRB (0.77) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6001446 | 0.77 | FGFR1 (1.00) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL378979 | 0.77 | FGFR1 (1.00) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5390359 | 0.77 | FGFR1 (1.00) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5365604 | 0.77 | KDR (0.47) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5368918 | 0.76 | PDGFRB (0.66) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL5373629 | 0.76 | PDGFRB (0.76) | PDGFRBFGFR1ALKABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | PDGFRB 52/4885FGFR1 112/4885ALK 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.