Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368885 | 0.86 | KDM4E (0.47) | PTPN1MDM2RETPLK4PLK1 | |
| SCHEMBL5358811 | 0.85 | MDM2 (0.46) | MDM2RETPLK4NPC1LRRK2 | |
| SCHEMBL7140043 | 0.84 | PTPN1 (0.49) | PTPN1MDM2RETPLK4PLK1 | |
| SCHEMBL5361625 | 0.84 | MDM2 (0.53) | MDM2RETLRRK2PDPK1 | |
| SCHEMBL7138246 | 0.84 | MDM2 (0.42) | MDM2PLK4PLK1LRRK2PDPK1 | |
| SCHEMBL7139982 | 0.84 | NPC1 (0.60) | MDM2PLK4NPC1 | |
| SCHEMBL5376996 | 0.82 | MEN1 (0.51) | MDM2PLK4PLK1NPC1LRRK2 | |
| SCHEMBL5366021 | 0.82 | KDM1A (0.53) | MDM2PLK4NPC1 | |
| SCHEMBL5373328 | 0.81 | LRRK2 (0.52) | MDM2RETPLK4PLK1LRRK2 | |
| SCHEMBL5357671 | 0.80 | LRRK2 (0.51) | MDM2RETLRRK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | PTPN1 882/4885MDM2 888/4885RET 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.