Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365939 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5366001 | 0.92 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365996 | 0.92 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365029 | 0.86 | MAPT (0.52) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365026 | 0.86 | MAPT (0.52) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5372829 | 0.84 | MAPT (0.54) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5372825 | 0.84 | MAPT (0.54) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365385 | 0.83 | GAA (0.54) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365381 | 0.83 | GAA (0.54) | SMN1; SMN2KDM4EGAAMAPTNPC1 | |
| SCHEMBL5365623 | 0.83 | MAPT (0.54) | SMN1; SMN2KDM4EGAAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349613-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2005-09-21 | — | — | EP | claimed |
| US-20040058990-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION | 2004-03-25 | — | — | US | claimed |
| EP-1349613-A2 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2003-10-08 | — | — | EP | claimed |
| WO-2002049413-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | claimed |
| US-7241783-B2 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1349613-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| US-20040058990-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION | 2004-03-25 | — | — | US | disclosed |
| EP-1349613-A2 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002049413-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058990-A1 | Thrombopoietin mimetics | MPL, THPO, TEK | SMN1; SMN2 2721/4885KDM4E 3460/4885GAA 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.