Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | RAF1 | P04049 | 5/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | ARAF | P10398 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | MYOC | Q99972 | 1/20 | 0.57 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.57 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27613119 | 0.85 | LRRK2 (0.71) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL6857818 | 0.85 | MAPT (0.70) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL13081136 | 0.85 | MAPT (0.70) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL6833732 | 0.85 | MAPT (0.70) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL13080521 | 0.85 | LRRK2 (0.71) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL5361840 | 0.84 | MAPT (0.66) | MAPTMAPK1HTTGSK3BRAF1 | |
| SCHEMBL5358659 | 0.84 | LRRK2 (0.69) | MAPTMAPK1HTTRAF1APP | |
| SCHEMBL5727967 | 0.82 | MAPT (1.00) | MAPTMAPK1HTTGSK3BAPP | |
| SCHEMBL5727969 | 0.82 | MAPT (1.00) | MAPTMAPK1HTTGSK3BAPP | |
| SCHEMBL13080906 | 0.81 | GSK3B (1.00) | MAPTMAPK1HTTGSK3BRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAPT 3048/4885MAPK1 424/4885HTT 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.