Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.55 |
| ▸ | POLB | P06746 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | NSD2 | O96028 | 1/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138197 | 0.83 | KMT2A (0.54) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL5367431 | 0.83 | RET (0.55) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL5364403 | 0.83 | KMT2A (0.56) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL5367226 | 0.79 | PTPN1 (0.44) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL7138230 | 0.78 | PTPN1 (0.43) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL7137036 | 0.78 | METAP1 (0.56) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL5358671 | 0.76 | RET (0.39) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL13044214 | 0.75 | KMT2A (0.67) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL6001821 | 0.73 | POLB (0.64) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL6001824 | 0.73 | POLB (0.64) | MEN1KMT2APOLBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MEN1 3855/4885KMT2A 4060/4885POLB 3294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.