Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 16/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.50 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.50 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368020 | 0.90 | GRIN2B (0.62) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5371193 | 0.87 | GRIN2B (0.59) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5358468 | 0.87 | GRIN2B (0.64) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5359935 | 0.87 | GRIN2B (0.61) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5368092 | 0.85 | GRIN2B (0.57) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5368572 | 0.85 | GRIN2B (0.67) | GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5368320 | 0.83 | GRIN2B (0.72) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5368102 | 0.81 | GRIN2B (0.72) | GRIN2BCYP2D6CYP2C9CYP3A4TPSAB1 | |
| SCHEMBL5378244 | 0.81 | GRIN2B (0.72) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL5370175 | 0.81 | GRIN2B (0.58) | NAPEPLDGRIN2BCYP2D6CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1390034-A4 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1390034-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK SHARP & DOHME CORP. | 2003-06-26 | — | — | US | disclosed |
| WO-2002080928-A1 | N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | GRIN1, GRIN2B, GRIN2A | NAPEPLD 973/4885GRIN2B 2/4885CYP2D6 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.