Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 6/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367274 | 0.87 | MEN1 (0.53) | IGF1RERN1PLK4PLK1DHFR | |
| SCHEMBL5368618 | 0.86 | ERN1 (0.46) | IGF1RERN1PLK4PLK1RAF1 | |
| SCHEMBL5366592 | 0.86 | LRRK2 (0.48) | IGF1RPLK4PLK1RAF1NTRK1 | |
| SCHEMBL5365740 | 0.85 | PTPN1 (0.51) | PLK4PLK1DHFRRAF1NTRK1 | |
| SCHEMBL7139555 | 0.83 | IGF1R (0.53) | IGF1RERN1PLK4PLK1DHFR | |
| SCHEMBL13856137 | 0.82 | IGF1R (0.63) | IGF1RERN1PLK4PLK1DHFR | |
| SCHEMBL7133980 | 0.82 | NPC1 (0.60) | PLK4PLK1DHFRRAF1NTRK1 | |
| SCHEMBL5363581 | 0.81 | ERN1 (0.48) | IGF1RERN1PLK4PLK1DHFR | |
| SCHEMBL5361530 | 0.79 | LRRK2 (0.49) | ERN1PLK4NTRK1MAPTRET | |
| SCHEMBL7134847 | 0.79 | KDM1A (0.58) | PLK4PLK1CDK2MAPTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | IGF1R 90/4885ERN1 1527/4885PLK4 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.