Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 19/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 19/20 | 0.70 |
| ▸ | PTPN5 | P54829 | 19/20 | 0.70 |
| ▸ | HSPD1 | P10809 | 9/20 | 0.70 |
| ▸ | HSPE1 | P61604 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375215 | 0.92 | PTPN2 (0.65) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5373826 | 0.92 | PTPN1 (0.74) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5382106 | 0.91 | PTPN2 (0.64) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5376781 | 0.90 | PTPN2 (0.68) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5373561 | 0.89 | PTPN2 (0.62) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5371930 | 0.85 | PTPN2 (0.60) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5370570 | 0.84 | KDM4E (0.62) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5368406 | 0.83 | PTPN1 (0.71) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL31701735 | 0.83 | PTPN2 (1.00) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL5371871 | 0.83 | MEN1 (0.57) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | PTPN2 2720/4885PTPN1 2340/4885PTPN5 2304/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | PTPN2 2602/4885PTPN1 2278/4885PTPN5 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.