Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.52 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | RECQL | P46063 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365967 | 0.86 | MOGAT2 (0.56) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5357966 | 0.86 | MOGAT2 (0.54) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5362575 | 0.86 | MOGAT2 (0.54) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5361437 | 0.85 | MOGAT2 (0.51) | MOGAT2MGAT2MEN1KMT2APDPK1 | |
| SCHEMBL5369910 | 0.84 | MGAT2 (0.55) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5367898 | 0.83 | MOGAT2 (0.56) | MOGAT2MGAT2MAPTLMNA | |
| SCHEMBL5358922 | 0.83 | PDPK1 (0.63) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5363246 | 0.82 | KDM4E (0.52) | MEN1KMT2AKDM4EMAPTRECQL | |
| SCHEMBL5363201 | 0.82 | MOGAT2 (0.55) | MOGAT2MGAT2MEN1KMT2AMAPT | |
| SCHEMBL5358368 | 0.82 | MOGAT2 (0.61) | MOGAT2MGAT2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MOGAT2 1159/4885MGAT2 4714/4885MEN1 3855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.