Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.70 |
| ▸ | FLT3 | P36888 | 4/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.70 |
| ▸ | KDR | P35968 | 6/20 | 0.67 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | CSF1R | P07333 | 2/20 | 0.64 |
| ▸ | FLT1 | P17948 | 2/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | FLT4 | P35916 | 2/20 | 0.64 |
| ▸ | SYK | P43405 | 2/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | GMNN | O75496 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365048 | 0.86 | RET (0.67) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL19978 | 0.83 | RET (1.00) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL19979 | 0.83 | RET (1.00) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL141995 | 0.82 | RET (0.61) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL5478517 | 0.80 | PDPK1 (1.00) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL31726696 | 0.80 | RET (0.76) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL29394706 | 0.80 | RET (1.00) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL13081086 | 0.80 | RET (1.00) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL5475962 | 0.80 | PDGFRB (0.81) | RETFLT3ALKPDGFRBKDR | |
| SCHEMBL2126784 | 0.80 | RET (1.00) | RETFLT3ALKPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | RET 283/4885FLT3 395/4885ALK 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.