Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | FEN1 | P39748 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354782 | 0.88 | KDR (0.65) | SLC6A2SLC6A4KDRKCNH2CHEK1 | |
| SCHEMBL5370412 | 0.82 | SLC6A2 (0.62) | SLC6A2SLC6A4KDRKCNH2CHEK1 | |
| SCHEMBL5371327 | 0.79 | SLC6A2 (0.56) | SLC6A2SLC6A4KDRKCNH2MAPT | |
| SCHEMBL5361067 | 0.79 | KDR (0.49) | SLC6A2SLC6A4KDRCHEK1ALOX5AP | |
| SCHEMBL5354528 | 0.78 | KDR (0.50) | SLC6A2SLC6A4KDRCHEK1ALOX5AP | |
| SCHEMBL5350566 | 0.76 | SLC6A2 (0.56) | SLC6A2SLC6A4KDRKCNH2ALOX5AP | |
| SCHEMBL5362169 | 0.72 | KDR (0.77) | KDRCHEK1ALOX5APFEN1 | |
| SCHEMBL5363140 | 0.69 | KDR (0.63) | KDRCHEK1 | |
| SCHEMBL143284 | 0.68 | KDR (0.65) | SLC6A2SLC6A4KDRKCNH2CHEK1 | |
| SCHEMBL5355525 | 0.68 | KDR (1.00) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |