Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyldopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | BLM | P54132 | 4/20 | 0.97 |
| ▸ | HPGD | P15428 | 4/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.97 |
| ▸ | POLB | P06746 | 3/20 | 0.97 |
| ▸ | APEX1 | P27695 | 3/20 | 0.97 |
| ▸ | RECQL | P46063 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | GAA | P10253 | 2/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.97 |
| ▸ | USP2 | O75604 | 2/20 | 0.97 |
| ▸ | EGFR | P00533 | 2/20 | 0.97 |
| ▸ | FYN | P06241 | 2/20 | 0.97 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyldopa (Racemic) SCHEMBL5929436 | 1.00 | KDM4E (0.97) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL30176814 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL1321546 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL34003 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL196981 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL29352376 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL1172822 | 0.98 | KDM4E (1.00) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL29013197 | 0.97 | KDM4E (0.97) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL259452 | 0.97 | KDM4E (0.97) | KDM4EHSD17B10TDP1MAPTBLM | |
| Methyldopa SCHEMBL11452341 | 0.97 | KDM4E (0.97) | KDM4EHSD17B10TDP1MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241797-B2 | Method of increasing milk production | UNIVERSITY OF CINCINNATI (US) | 2007-07-10 | — | — | US | disclosed |
| US-20030139420-A1 | Method of increasing milk production | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-07-24 | — | — | US | disclosed |
| US-5240930-A | Yohimbine with catecholamine precursor | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1993-08-31 | — | — | US | disclosed |
| EP-0345304-B1 | PHARMACEUTICAL COMPOSITIONS | BTG INTERNATIONAL LIMITED (GB) | 1992-10-28 | — | — | EP | disclosed |
| US-5015654-A | Pharmaceutical compositions | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-05-14 | — | — | US | disclosed |
| EP-0345304-A1 | PHARMACEUTICAL COMPOSITIONS | BTG INTERNATIONAL LIMITED (GB) | 1989-12-13 | — | — | EP | disclosed |
| WO-1989001774-A1 | PHARMACEUTICAL COMPOSITIONS | SAAD AL DAMLUJI (GB) | 1989-03-09 | — | — | WO | disclosed |