Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.61 |
| ▸ | PPARA | Q07869 | 11/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | PPARD | Q03181 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382421 | 0.93 | FFAR1 (0.71) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5380833 | 0.87 | FFAR1 (0.65) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5377238 | 0.85 | FFAR1 (0.65) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5397157 | 0.85 | FFAR1 (0.59) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5387848 | 0.84 | FFAR1 (0.59) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL7897351 | 0.84 | FFAR1 (0.83) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5392056 | 0.84 | FFAR1 (0.58) | PPARGPPARAFFAR1 | |
| SCHEMBL5372174 | 0.84 | FFAR1 (0.58) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5380371 | 0.83 | PPARG (0.60) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL5380970 | 0.82 | FFAR1 (0.58) | PPARGPPARAFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |