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SCHEMBL5372780

SCHEMBL5372780

CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CCNC(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)c1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 20/20 0.55
▸ BACE2 Q9Y5Z0 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5367173 0.94 BACE1 (0.53) BACE1BACE2
SCHEMBL5376061 0.90 BACE1 (0.54) BACE1BACE2
SCHEMBL6798360 0.90 BACE1 (0.57) BACE1BACE2
SCHEMBL14425955 0.90 BACE1 (0.50) BACE1BACE2
SCHEMBL5375476 0.90 BACE1 (0.50) BACE1BACE2
SCHEMBL14425891 0.90 BACE1 (0.44) BACE1BACE2
SCHEMBL6803706 0.90 BACE1 (0.56) BACE1BACE2
SCHEMBL5372954 0.88 BACE1 (0.63) BACE1BACE2
SCHEMBL5372971 0.88 BACE1 (0.57) BACE1BACE2
SCHEMBL14425976 0.88 BACE1 (0.57) BACE1BACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7262208-B2 Hydroxypropyl amides for the treatment of Alzheimer's disease ELAN PHARMACEUTICALS, INC. (US) 2007-08-28 — — US claimed