Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | SYK | P43405 | 16/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059607 | 0.88 | AURKA (0.70) | AURKAAURKBSYK | |
| SCHEMBL4056297 | 0.71 | AURKA (1.00) | AURKAAURKBSYK | |
| SCHEMBL4057413 | 0.69 | SYK (0.69) | AURKAAURKBSYK | |
| SCHEMBL4057028 | 0.68 | SYK (0.92) | AURKAAURKBSYK | |
| SCHEMBL4056832 | 0.68 | SYK (1.00) | AURKAAURKBSYK | |
| SCHEMBL4057518 | 0.68 | SYK (1.00) | AURKAAURKBSYK | |
| SCHEMBL4057432 | 0.67 | SYK (0.75) | AURKAAURKBSYK | |
| SCHEMBL4271436 | 0.66 | SYK (0.74) | AURKAAURKBSYK | |
| SCHEMBL4061646 | 0.66 | SYK (1.00) | AURKAAURKBSYK | |
| SCHEMBL4056861 | 0.66 | SYK (1.00) | AURKAAURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | claimed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | claimed |