Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035848 | 0.86 | KDM4E (0.76) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL5372209 | 0.86 | KMT2A (1.00) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL2031582 | 0.85 | KDM4E (0.74) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL2031887 | 0.85 | KDM4E (0.74) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL3314663 | 0.84 | KDM4E (0.73) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL5373531 | 0.84 | KDM4E (0.73) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL2036696 | 0.84 | KDM4E (0.72) | KDM4EMEN1KMT2APOLBRAB9A | |
| SCHEMBL5368898 | 0.83 | KDM4E (0.71) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL5377213 | 0.83 | KDM4E (1.00) | KDM4EMEN1KMT2APOLBNPC1 | |
| SCHEMBL2035459 | 0.83 | KDM4E (0.71) | KDM4EMEN1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202244-B2 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202244-B2 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202244-B2 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20040014765-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014765-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | KDM4E 1251/4885MEN1 1973/4885KMT2A 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.