Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL247964 | 0.90 | TSHR (0.78) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Ethylene Glycol SCHEMBL1401169 | 0.90 | TSHR (0.78) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Butyl Alcohol SCHEMBL15004902 | 0.89 | TSHR (0.61) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Alcohol SCHEMBL23702395 | 0.87 | TSHR (0.74) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Alcohol SCHEMBL27846676 | 0.87 | TSHR (0.74) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Propane SCHEMBL27531646 | 0.87 | TSHR (0.82) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Butyl Alcohol SCHEMBL28312338 | 0.87 | TSHR (0.58) | TSHRLMNACHRM2CHRM4CHRM1 | |
| 1-Pentanol SCHEMBL11376862 | 0.87 | TSHR (0.58) | TSHRLMNAMAPTSMN1; SMN2PRKCA | |
| Pentane SCHEMBL4454016 | 0.85 | TSHR (0.70) | TSHRLMNACHRM2CHRM4CHRM1 | |
| Hexane SCHEMBL372207 | 0.85 | TSHR (0.70) | TSHRLMNACHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117384045-A | Preparation method of pharmaceutical grade sitagliptin chloride | 广东先强药业有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-113527106-B | Preparation method of pharmaceutical grade sitagliptin chloride | 广东先强药业有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-113527106-A | Preparation method of medicinal-grade sitaglinium chloride | 广东先强药业有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2019164778-A1 | PROCESS FOR PREPARING 1-ARYLSULFONYL-PYRROLIDINE-2-CARBOXAMIDE TRANSIENT RECEPTOR POTENTIAL CHANNEL ANTAGONIST COMPOUNDS AND CRYSTALLINE FORMS THEREOF | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| EP-2948432-A1 | PROCESS FOR MAKING IVABRADINE | Synthon BV (NL) | 2015-12-02 | — | — | EP | disclosed |
| US-8967491-B2 | Method of treating target space, and liquid particles | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-03-03 | — | — | US | disclosed |
| WO-2014114341-A1 | PROCESS FOR MAKING IVABRADINE | SYNTHON BV (NL) | 2014-07-31 | — | — | WO | disclosed |
| US-20130313335-A1 | METHOD OF TREATING TARGET SPACE, AND LIQUID PARTICLES | SUMITOMO CHEMICAL COMPANY, LIMITED | 2013-11-28 | — | — | US | disclosed |
| EP-2658584-A1 | METHOD OF TREATING TARGET SPACE, AND LIQUID PARTICLES | Sumitomo Chemical Company Limited (JP) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012090683-A1 | METHOD OF TREATING TARGET SPACE, AND LIQUID PARTICLES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-07-05 | — | — | WO | disclosed |
| US-7160953-B2 | Polymeric surface coatings | BIOCOMPATIBLES UK LIMITED (GB) | 2007-01-09 | — | — | US | disclosed |
| US-20040176556-A1 | Polymeric surface coatings | BIOCOMPATIBLES LIMITED | 2004-09-09 | — | — | US | disclosed |
| US-6743878-B2 | FOR IMPROVED BIOCOMPATIBILITY/HAEMOCOMPATIBILITY WITH LIVING TISSUES | BIOCOMPATIBLES UK LIMITED (GB) | 2004-06-01 | — | — | US | disclosed |
| US-20030190405-A1 | Polymeric surface coatings | BIOCOMPATIBLES LIMITED | 2003-10-09 | — | — | US | disclosed |
| US-6432314-B1 | ION EXCHANGERS AND SCAVENGERS FOR BLOOD PURIFICATION | BIOCOMPATIBLES LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |
| EP-0939779-B1 | ANION EXCHANGE MATERIALS AND PROCESSES | BIOCOMPATIBLES LTD (GB) | 2002-04-10 | — | — | EP | disclosed |
| US-6251964-B1 | CATIONIC TERPOLYMER | BIOCOMPATIBLES LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |
| US-6090901-A | Polymeric surface coatings | BIOCOMPATIBLES LIMITED (GB) | 2000-07-18 | — | — | US | disclosed |
| EP-0866815-B1 | BIOCOMPATIBLE COMPOSITIONS | BIOCOMPATIBLES LTD (GB) | 2000-02-23 | — | — | EP | disclosed |