Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365947 | 0.90 | MEN1 (0.48) | MAPK14MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL5378327 | 0.85 | CCR3 (0.40) | MAPK14CCR3 | |
| SCHEMBL5732819 | 0.80 | MEN1 (0.46) | MAPK14MEN1KMT2ACCR3CYP2C9 | |
| SCHEMBL5374169 | 0.76 | MAPK14 (0.42) | MAPK14MEN1KMT2A | |
| SCHEMBL5383884 | 0.75 | GAA (0.47) | MAPK14MEN1KMT2ACCR3CYP2C9 | |
| SCHEMBL5376287 | 0.74 | MAPK14 (0.43) | MAPK14CCR3 | |
| SCHEMBL5201672 | 0.70 | MEN1 (0.57) | MAPK14MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL5806708 | 0.66 | MEN1 (0.55) | MAPK14MEN1KMT2ACCR3CYP2C9 | |
| SCHEMBL5204083 | 0.66 | CYP2C9 (0.52) | MAPK14MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL7443112 | 0.65 | MEN1 (0.52) | MAPK14MEN1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | claimed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-6340685-B1 | ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-01-22 | — | — | US | disclosed |