SCHEMBL5374191

SCHEMBL5374191

CCc1ccc(Cc2cc(C)c(=O)[nH]n2)c(F)c1Oc1cc(C#N)cc(C#N)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.75
CYP2C9 P11712 2/20 0.75
CYP2C19 P33261 2/20 0.75
KCNH2 Q12809 4/20 0.44
PGR P06401 1/20 0.33
SLC5A2 P31639 1/20 0.33
EPAS1 Q99814 1/20 0.31
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
ALOX12 P18054 1/20 0.30
KMT2A Q03164 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
BCAT2 O15382 1/20 0.30
BCAT1 P54687 1/20 0.30
PRMT5 O14744 1/20 0.30
WDR77 Q9BQA1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5668069 0.93 CYP3A4 (0.76) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL4279184 0.91 CYP3A4 (0.74) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL4274657 0.90 CYP3A4 (0.91) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL14214335 0.90 CYP3A4 (0.73) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL4270152 0.87 CYP3A4 (0.68) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL5375519 0.87 CYP3A4 (0.76) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL4272969 0.86 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL5368425 0.86 CYP3A4 (0.86) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL4274479 0.86 CYP3A4 (0.86) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2
SCHEMBL5370521 0.84 CYP3A4 (0.67) CYP3A4CYP2C9CYP2C19KCNH2SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7189718-B2 Non-nucleoside reverse transcriptase inhibitors ROCHE PALO ALTO LLC (US) 2007-03-13 US disclosed
US-7189718-B2 Non-nucleoside reverse transcriptase inhibitors ROCHE PALO ALTO LLC (US) 2007-03-13 US disclosed
EP-1730120-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2006-12-13 EP disclosed
WO-2005090317-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2005-09-29 WO disclosed