Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 1/20 | 0.49 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371907 | 0.90 | POLB (0.68) | SMN1; SMN2POLBLMNAALDH1A1WDR5 | |
| SCHEMBL5371829 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBLMNAPLAUALDH1A1 | |
| SCHEMBL5376792 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBLMNAALDH1A1WDR5 | |
| SCHEMBL5368290 | 0.87 | PLAU (0.53) | SMN1; SMN2POLBLMNAPLAUALDH1A1 | |
| SCHEMBL5373265 | 0.85 | KMT2A (0.64) | SMN1; SMN2POLBPLAUMGAT2 | |
| SCHEMBL5380693 | 0.83 | POLB (0.62) | SMN1; SMN2POLBPLAUMGAT2PLAT | |
| SCHEMBL5391335 | 0.83 | POLB (0.54) | SMN1; SMN2POLBPLAUWDR5IDH1 | |
| SCHEMBL5368389 | 0.83 | POLB (0.60) | SMN1; SMN2POLBLMNAPLAUPLAT | |
| SCHEMBL5377045 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBLMNAALDH1A1WDR5 | |
| SCHEMBL5372094 | 0.82 | POLB (0.53) | SMN1; SMN2POLBLMNAPLAUALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | SMN1; SMN2 3404/4885POLB 1807/4885LMNA 319/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | SMN1; SMN2 3296/4885POLB 2006/4885LMNA 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.