Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620688 | 0.78 | TDP1 (0.69) | MAPTGAATDP1ALDH1A1RAB9A | |
| SCHEMBL2477935 | 0.75 | NPC1 (0.57) | MAPTTDP1ALDH1A1HPGDRAB9A | |
| SCHEMBL537486 | 0.74 | KMT2A (0.54) | MAPTGAAPOLBALDH1A1HPGD | |
| SCHEMBL682171 | 0.74 | GAA (0.57) | MAPTGAAALDH1A1HPGDKDM4E | |
| SCHEMBL11720274 | 0.74 | MAPT (0.58) | MAPTGAATDP1ALDH1A1HPGD | |
| SCHEMBL17831407 | 0.73 | KMT2A (0.51) | MAPTGAAPOLBALDH1A1RAB9A | |
| SCHEMBL328491 | 0.73 | GAA (0.56) | MAPTGAAALDH1A1HPGDRAB9A | |
| SCHEMBL3604286 | 0.73 | KMT2A (0.74) | MAPTALDH1A1RAB9A | |
| SCHEMBL537509 | 0.73 | GAA (0.49) | MAPTGAAALDH1A1RAB9AKDM4E | |
| SCHEMBL12426304 | 0.72 | CNR2 (0.60) | CNR2MAPTGAAPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414366-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | Novartis AG (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112520-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | NOVARTIS AG (CH) | 2010-10-07 | — | — | WO | disclosed |